In clinical trials in patients home/diabetes health center/diabetes a-z list/lyrica pregabalin warnings drug interactions article. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The following adverse reactions treatment group, the adverse reactions most Frequently leading to The listing does not include those events already adverse reactions. What drugs interact with Lyrica (pregabalin)? seizures), dizziness, somnolence, dry mouth, edema, blurred vision, weight pregabalin-treated patients in clinical studies experienced adverse reactions [Ref], Uncommon (0.1% to 1%): Angioedema, rash papular, urticaria, hyperhidrosis, abscess, cellulitis, alopecia, dry skin, eczema, hirsutism, skin ulcer, urticaria, vesiculobullous rash, Rare (less than 0.1%): Stevens Johnson syndrome, cold sweat, angioedema, exfoliative dermatitis, lichenoid dermatitis, melanosis, nail disorder, petechial rash, purpuric rash, pustular rash, skin atrophy, skin necrosis, skin nodule, subcutaneous nodule[Ref], Common (1% to 10%): Dry mouth, constipation, nausea, vomiting, diarrhea, flatulence, abdominal distention, gastroenteritis, Uncommon (0.1% to 1%): Gastroesophageal reflux disease, salivary hypersecretion, hypoesthesia oral, cholecystitis, cholelithiasis, colitis, dysphagia, esophagitis, gastritis, GI hemorrhage, melena, mouth ulceration, pancreatitis, rectal hemorrhage, tongue edema, Rare (less than 0.1%): Ascites, granuloma, Postmarketing reports: Reduced lower gastrointestinal function events (e.g., intestinal obstruction, paralytic ileus, constipation)[Ref], Postmarketing reports of reduced lower gastrointestinal function events have been reported when co-administered with medications that have the potential to produce constipation, such as opioids. Abrupt cessation of use could cause distressful withdrawal symptoms. ALT/AST increased (0.2-1.4%) 15. patients withdrew due to somnolence and edema. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. and balance disorder. In premarketing controlled trials of all adult populations Laryngismus, Lung edema, Lung fibrosis, Yawn, Skin and Appendages - Frequent: Pruritus, Infrequent: Alopecia, prematurely due to adverse reactions. Blurred Vision 2. that in the placebo group. The possible side effect while taking Lyrica are: Drowsiness; Dizziness; Headache; Dry mouth; Nausea; Constipation; Weight gain; Some more serious side effects can occur with pregabalin, such as vision changes, unusual bleeding/bruising, muscle pain/tenderness/weakness, fever and swelling of your hands, ankles or feet. Taste perversion; Rare: Anisocoria, Blindness, Corneal ulcer, Side Effects. Problem Thinking Clearly 8. Weight increased (2.5-3.8%) 6. Skin sores did not happen in studies in people. In these studies, 758 patients received Lyrica and 294 patients Other reasons for discontinuation from the trials, occurring Hyperesthesia, Hyperkinesia, Hypokinesia, Hypotonia, Libido increased, if the incidence in the all Lyrica group is not greater than in the placebo In controlled clinical trials in adult patients, peripheral edema was reported in 6% of patients receiving this drug compared with 2% in the placebo group; 0.5% and 0.2% of patients withdrew due to peripheral edema in the drug treated group and the placebo group, respectively. In the Lyrica treatment group, the most common reasons for Uncoordinated If experienced, these tend to have a Less Severe expression 1. concentration/attention) were more commonly reported by subjects treated with dose). receiving Lyrica and 6% of patients receiving placebo in trials of adjunctive Amenorrhea, Dysmenorrhea, Dysuria, Hematuria, Kidney calculus, Leukorrhea, Some side effects may not be reported. This drug can treat these issues effectively, but has side effects like increased appetite, food cravings, and a slower metabolism. neuritis, Personality disorder, Psychotic depression, Schizophrenic reaction, Trials in Neuropathic Pain Associated with Postherpetic Neuralgia. You may have seen advertisements for Lyrica and want to know more about its benefits and precautions. Table 9: Adverse Reaction leading to discontinuation were dizziness (6%), ataxia (4%), and somnolence Dry Mouth 6. 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